Gun Ownership in the United States: Measurement Issues and Trends

Gun violence is a serious problem in the United States. In 2011, 478,400 violent crimes were committed with a firearm (Planty and Truman, 2013). While down dramatically since the 1990s, the rate of non-fatal firearm victimizations rose from 2008 to 2011. Firearms deaths from all causes (homicides, suicides, accidental, and undetermined) averaged over 31,000 annually in 2005-2011 (CDC WISQARS, 2013; Hoyert and Xu, 2012). Non-fatal gunshot injuries totaled 81,396 in 2012; a rise in the injury rate per 100,000 from 20.5 in 2002 to 25.9 in 2012 (CDC, 2013).Given the magnitude and seriousness of gun violence, it is important to have accurate and reliable information on the possession and use of firearms in the United States. This report examines one crucial element, the level of and trends in household and personal gun ownership. First, the report considers methodological issues concerning the measurement of gun ownership. Second, it examines trends in gun ownership. Third, it evaluates the nexus of these two factors, the impact of methodological issues on the measurement of trends gun ownership. Finally, it considers what ancillary trend data on crime, hunting, household size, and number of guns available suggest about trends in gun ownership

Women’s Involvement in Adult Education and Family Literacy: Consequences for Social Networks, Social Support, and Mental Health

This paper presents preliminary findings from a mixed-methods study that examines how women use adult education and family literacy programs to construct supportive social networks, and, in turn, how these influence their mental health. We argue that these programs offer opportunities to form friendships and to access emotional, informational, and material support, thereby alleviating psychological distress arising from poverty, caregiving, and other stressors. However, intentional efforts to cultivate social ties and support systems among adult learners are needed

Enhancing Fieldwork Futures: race and inclusion in Geography field trips

Fieldwork is integral to studying Geography. It is recognized in the QAA Subject Benchmark (2022) and in the requirements for accreditation by the professional body (RGS-IBG, no date). Fieldwork has pedagogical and social benefits (Marvell and Sim 2018; Stokes et al. 2011; Wheeler et al. 2011). Maximising out-of-class academic experiences increases informal interactions among students and staff, enabling the development of ‘field-based learning communities’ (Skop, 2014). However, recent research has exposed counter-narratives to this, in terms of inclusivity and accessibility for participants, particularly in relation to ‘protected characteristics’ (UK Equality Act, 2010) such as race (Foster, 2021; Hughes, 2016), disability (Lawrence and Dowey, 2022) and sexuality (Sou, 2021). This project draws upon interviews with students to explore how Geography fieldwork can be made more accessible and inclusive to Global Ethnic Majority students

Capacity precommitment as a barrier to entry: a Bertrand-Edgeworth approach

This paper considers the role of capacity as a strategic entry deterrent for a game in which the incumbent and entrant sequentially precommit to capacity levels before competing in price, possibly using mixed strategies. Depending on the magnitudes of the fixed set-up cost, the cost of capacity, and the relative costs of production, the model produces a wide spectrum of equilibrium behaviors, including some not previously suggested in the literature. Interesting deterrence effects occur because firms need time to build. In contrast to much previous work, the incumbent may hold idle capacity when entry is deterred.Competition

The Grizzly, April 11, 1995

ProTheatre Stages Our Country\u27s Good • Congratulations to the New Phi Beta Kappa Members • Letter to the Editor: Where Have All Our Leaders Gone?; Gay Rights at Ursinus • Quiet Please! • Hello, This is the Phone Mail System • Why Examine Curriculum? • Student Exhibition to Open April 25 • Course Preview: Women in Politics • Final Exam Schedule • Environmental Club Activities Planned to Commemorate Earth Day • Alumnae Spotlight: Kim Caffey • Baseball Team Earns Big Win Over Hopkins • Men\u27s Tennis Gets First Win • Golfers Placed Second at Gettysburg • Women\u27s Tennis Looking for First Win • Trecroce Keys Ursinus Sweep as Softball Team Stays in the Race • Kiwak Named Player of the Week • Landis Named Player of the Week • Cosgrove Honored • Lacrosse Unbeaten in Conference Playhttps://digitalcommons.ursinus.edu/grizzlynews/1359/thumbnail.jp

Aquilegia, Vol. 18 No. 4, July-August 1994: Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1072/thumbnail.jp

Comparative analysis of module-based versus direct methods for reverse-engineering transcriptional regulatory networks

We have compared a recently developed module-based algorithm LeMoNe for reverse-engineering transcriptional regulatory networks to a mutual information based direct algorithm CLR, using benchmark expression data and databases of known transcriptional regulatory interactions for Escherichia coli and Saccharomyces cerevisiae. A global comparison using recall versus precision curves hides the topologically distinct nature of the inferred networks and is not informative about the specific subtasks for which each method is most suited. Analysis of the degree distributions and a regulator specific comparison show that CLR is 'regulator-centric', making true predictions for a higher number of regulators, while LeMoNe is 'target-centric', recovering a higher number of known targets for fewer regulators, with limited overlap in the predicted interactions between both methods. Detailed biological examples in E. coli and S. cerevisiae are used to illustrate these differences and to prove that each method is able to infer parts of the network where the other fails. Biological validation of the inferred networks cautions against over-interpreting recall and precision values computed using incomplete reference networks.Comment: 13 pages, 1 table, 6 figures + 6 pages supplementary information (1 table, 5 figures

Clinical characteristics and outcomes of IgD myeloma: experience across UK national trials

© 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.Immunoglobulin D (IgD) myeloma is a subtype often considered to have adverse features and inferior survival, but there is a paucity of data from large clinical studies. We compare the clinical characteristics and outcomes of patients with IgD myeloma from UK phase 3 myeloma trials analyzed in 2 groups: old (1980-2002) and recent (2002-2016) clinical trials, based on the time of adoption of novel myeloma therapies. Patients with IgD myeloma comprised 44 of 2789 (1.6%) and 70 of 5773 (1.2%) of the old and recent trials, respectively. Overall, IgD myeloma was associated with male predominance, low-level paraproteinemia (,10g/L), and l light chain preference. The frequency of ultra-high-risk cytogenetics was similar in IgD myeloma compared with other subtypes (4.3% vs 5.3%, P . .99). Despite the old trial series being a younger group (median age: 59 vs 63 years, P 5 .015), there was a higher frequency of bone lesions, advanced stage at diagnosis, worse performance status, and severe renal impairment compared with the recent trials. Furthermore, the early mortality rate was significantly higher for the old trial series (20% vs 4%, P 5 .01). The overall response rate following induction therapy was significantly higher in the recent trials (89% vs 43%, P, .0001), and this was consistent with improved median overall survival (48 months; 95% confidence interval [CI] 35-67 months vs 22 months; 95% CI, 16-29 months). Survival outcomes for IgD myeloma have significantly improved and are now comparable to other myeloma types because of earlier diagnosis, novel therapies, and improved supportive care.Published versio

Clinical characteristics and outcomes of IgD myeloma : experience across UK national trials

Immunoglobulin D (IgD) myeloma is a subtype often considered to have adverse features and inferior survival, but there is a paucity of data from large clinical studies. We compare the clinical characteristics and outcomes of patients with IgD myeloma from UK phase 3 myeloma trials analyzed in 2 groups: old (1980-2002) and recent (2002-2016) clinical trials, based on the time of adoption of novel myeloma therapies. Patients with IgD myeloma comprised 44 of 2789 (1.6%) and 70 of 5773 (1.2%) of the old and recent trials, respectively. Overall, IgD myeloma was associated with male predominance, low-level paraproteinemia ( .99). Despite the old trial series being a younger group (median age: 59 vs 63 years, P = .015), there was a higher frequency of bone lesions, advanced stage at diagnosis, worse performance status, and severe renal impairment compared with the recent trials. Furthermore, the early mortality rate was significantly higher for the old trial series (20% vs 4%, P = .01). The overall response rate following induction therapy was significantly higher in the recent trials (89% vs 43%, P < .0001), and this was consistent with improved median overall survival (48 months; 95% confidence interval [CI] 35-67 months vs 22 months; 95% CI, 16-29 months). Survival outcomes for IgD myeloma have significantly improved and are now comparable to other myeloma types because of earlier diagnosis, novel therapies, and improved supportive care. This trial was registered at clinicaltrials.gov as # NCT01554852